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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Fyn depletion ameliorates tauP301L-induced neuropathology

Fig. 7

Fyn depletion prevented tauP301L induced synaptic protein degradation. a Synaptosome preps from WT and Fyn KO uninjected mice, WT-AAV, and Fyn KO-AAV mice were probed for NR2B, PSD95, and Fyn. 7 WT, 10 WT-AAV, 6 Fyn KO, and 11 Fyn KO-AAV were used. b Compared to WT uninjected mice, WT-AAV had significantly decreased concentrations of PSD95, (p = 0.027) and Fyn (p = 0.0024); using t-test, a decreased concentration of NR2B (p = 0.0304), was also observed. In contrast, relative to Fyn KO uninjected mice, Fyn KO-AAV had no difference in the concentrations of PSD95 (p = 0.2519) or NR2B (p = 0.6533). There was also no difference between WT and Fyn KO uninjected mice for PSD95 (p = 0.4378) and NR2B (p = 0.9986). Two-way ANOVA with Tukey’s post hoc multiple comparisons were used for PSD95 and NR2B panels. T-test was used for Fyn. Statistical results are shown in SI Table 1

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