Fig. 4

Fyn depletion modulated tau^P301L-induced microgliosis. a WT-AAV had increased total number of Iba1 positive cells in the hippocampus relative to WT uninjected; no such change was found when comparing Fyn KO uninjected and Fyn KO-AAV mice. b WT-AAV had increased total area of GFAP positive staining in the hippocampus relative to WT uninjected; no such change was found when comparing Fyn KO uninjected and Fyn KO-AAV mice. c In the hippocampus, WT-AAV showed an increase in total number of Iba1 positive cells relative to WT uninjected (p = 0.0002) while Fyn KO-AAV did not show any increase relative to Fyn KO uninjected (p = 0.9027) or to WT uninjected (p = 0.9954). Fyn KO-AAV was significantly less relative to WT-AAV (p = 0.0002). d In the hippocampus, WT-AAV showed an increase in percent GFAP positive area relative to WT uninjected (p = 0.0087) while Fyn KO-AAV did not show any increase relative to Fyn KO uninjected (p = 0.9473), WT uninjected (p = 0.1712), or WT-AAV (p = 0.2115). 3 mice from each group was examined. Scale bar: 25 μm. Two-way ANOVA with Tukey’s post hoc multiple comparisons was used for panels C and D. Statistical results are shown in SI Table 1