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Table 1 Semi-quantitative assessment and regional distribution of tau pathology on brain sections immunolabelled with AT8. -: absent; +: occasional; ++: moderate number; +++: frequent number. NFT, neurofibrillary tangles

From: de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia

  Tau pathology
Brain areas NFT Neuronal diffuse Oligodendroglial Astrocytic
Hippocampal pyramidal layer +++ +++ ++ +
Dentate gyrus +
Subiculum ++ ++ + +
Transentorhinal cortex + + + +
Temporal cortex ++ ++ ++ +
Frontal cortex ++ + ++ +
Cingulate cortex + + + +
Visual cortex
Striatum ++ + +++ +
Globus pallidus ++ + + +
Thalamus ++ + + +
Substantia nigra +++ + + +
Pontine nuclei ++ + + +
Olivary Nuclei +