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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma

Fig. 3

Histologic features of MYCN amplified spinal cord ependymomas, representative case 1 (A-E, H&E). a, b. Classical neuroectodermal ependymoma-like features showing typical cellular composition and pseudorosettes (a. 100x, b. 200x). c, d, e. Atypical high-grade associated features: c. vascular proliferation (100x), d. focal necrosis (100x), e. hyperchromatic tumor nuclei with prominent pink nucleoli and increased mitoses (400x) f. MIB1 immunostain demonstrating high proliferation rate (~‚ÄČ20%) in case 5 (100x)

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