Fig. 3
Cerebrovascular TIMP3 expression in CAA-NH and CAA-ICH cases. Representative example of TIMP3 staining in a CAA-NH case (a), a CAA-ICH case with high TIMP3 expression (b), and a CAA-ICH case with many vessels negative for TIMP3 and only few TIMP3- positive vessels (c). Scale bar = 100 μm (a). The percentage of TIMP3-stained (full or partial) leptomeningeal vessels was lower in CAA-ICH cases compared to CAA-NH cases, an effect driven by a subgroup of CAA-ICH cases with a substantially lower percentage of TIMP3-stained vessels (open triangles) (b). The numbers of cortical vessels stained per cm2 did not differ between CAA-ICH cases and CAA-NH cases, although the cases with low TIMP3 expression in leptomeningeal vessels had also low expression in cortical vessels (open triangles) (c). Plots indicate median values with interquartile range. CAA-NH = CAA-non haemorrhagic, CAA-ICH = CAA-related ICH. **p ≤ 0.01