Fig. 1

Immunohistochemistry for hp-tau and p-αSyn in the amygdala of rTg4510 mice fed the standard or doxycycline diet and control mice. rTg4510 mice developed numerous hp-tau-positive aggregates stained with the anti-hp-tau antibody AT8 (a, b), while control mice did not (c). rTg4510 mice also developed numerous, p-αSyn-positive aggregates stained with the anti-p-αSyn antibody D1R1R (d, e), 81A (g, h), and EP1536Y (j, k), while control mice did not (f, i, l). Scale bar: 20 μm (a-l)