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Table 1 ToppGene Pathways enriched in ALS choroid plexus

From: Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis

Pathway IDNamep-valueq-value BonferroniHit Count in ListHit Count in GenomeHit in Query List
1,269,530Signaling by NOTCH2.38E-067.21E-0335113ADAM10,ARRB1,ARRB2,HDAC3,HDAC9,HDAC4,MAML1,ITCH,HDAC5,MAMLD1,HEYL,EP300,FCER2,ST3GAL6,HDAC7,TMED2,LFNG,MFNG,MOV10,NOTCH1,NOTCH2,NOTCH3,NOTCH4,FURIN,NEURL1B,MAML3,SKP1,PSENEN,NCSTN,HEY1,TLE1,TLE2,TLE3,HEY2,TP53
P00019Endothelin signaling pathway9.20E-062.79E-022573ADCY2,ADCY3,ADCY5,ADCY7,ADCY4,PIK3R3,SEC11C,ECE1,EDN2,GNA11,GNAL,ITPR1,ITPR3,FURIN,PIK3C2A,PIK3C2B,PIK3C3,PIK3CD,PLCB2,PLCB3,PRKAR1A,PRKAR2B,PRKCE,PRKCI,SEC11A
PW:0000204Notch signaling2.85E-058.64E-021535ADAM10,NEURL2,MAML1,HEYL,LFNG,MFNG,NOTCH1,NOTCH2,NOTCH3,NOTCH4,MAML3,PSENEN,NCSTN,HEY1,HEY2
1,269,535Signaling by NOTCH13.86E-051.17E-012474ADAM10,ARRB1,ARRB2,HDAC3,HDAC9,HDAC4,MAML1,ITCH,HDAC5,MAMLD1,HEYL,EP300,HDAC7,NOTCH1,NEURL1B,MAML3,SKP1,PSENEN,NCSTN,HEY1,TLE1,TLE2,TLE3,HEY2
952,858Platelet activation4.82E-051.46E-0134123ADCY2,ADCY3,ADCY5,ADCY7,ADCY4,PIK3R3,PLA2G4C,ARHGEF1,COL1A1,COL1A2,COL3A1,RASGRP2,FCGR2A,GNA13,GNAI3,GUCY1B1,ITPR1,ITPR3,MYLK,PIK3CD,PLCB2,PLCB3,PLCG2,APBB1IP,PRKCI,MAPK11,MAPK13,RAP1B,MAPK12,SRC,TBXA2R,TLN1,VWF,P2RY12
P00034Integrin signaling pathway7.63E-052.31E-0142167PIK3R3,ITGA10,ITGA8,RHOB,ARL1,CDC42,COL1A1,COL1A2,COL3A1,COL5A1,COL6A1,COL6A2,COL6A3,COL7A1,COL8A1,COL9A3,COL11A1,COL15A1,COL16A1,ELMO1,DNAJC27,LAMC3,PTK2B,ITGA3,ITGA9,LAMA2,MAP3K3,PIK3C2A,PIK3C2B,PIK3C3,PIK3CD,MAPK6,MAPK13,PXN,RAP1B,ITGA11,SHC1,LIMS2,PARVA,SRC,TLN1,COL14A1
102,279Endocytosis7.97E-052.42E-0159260CLTCL1,ADRB1,GRK2,AP2A1,AP2A2,PIP5K1B,AMPH,ARRB1,ARRB2,RAB11A,CAPZA1,CAPZA2,CBL,USP8,CDC42,RAB11B,CYTH2,CYTH1,CLTB,VPS26A,RAB11FIP3,ACAP1,ZFYVE16,CHMP7,ARFGAP3,DNM2,ITCH,WASHC3,ERBB4,FGFR3,ACAP3,VTA1,ARFGAP2,CYTH4,EHD1,GRK5,SNF8,HLA-F,HSPA1A,HSPA8,KIF5B,CHMP1A,WIPF3,PLD2,PML,SH3KBP1,PRKCI,RAB4A,EHD3,EHD2,SH3GL3,VPS35,SRC,RBSN,TGFB1,ARAP3,PARD3,CBLC,WIPF1
908,257Adrenergic signaling in cardiomyocytes1.24E-043.77E-0137144ADCY2,ADCY3,ADCY5,ADCY7,ADRA1D,ADRB1,ADCY4,ATP1B1,ATP2B4,CACNA1C,CACNA2D1,CACNB3,CACNB4,CALM1,CAMK2B,CREB3L4,RPS6KA5,CACNA2D2,ATF2,ATF6B,CREM,RAPGEF3,GNAI3,KCNE1,MYH6,MYL3,PLCB2,PLCB3,PPP2R3A,PPP2R5C,MAPK11,MAPK13,MAPK12,SCN1B,SCN4B,CACNA2D3,TPM2
1,269,537NOTCH1 Intracellular Domain Regulates Transcription1.52E-044.62E-011748HDAC3,HDAC9,HDAC4,MAML1,HDAC5,MAMLD1,HEYL,EP300,HDAC7,NOTCH1,MAML3,SKP1,HEY1,TLE1,TLE2,TLE3,HEY2
121,494Dilated cardiomyopathy1.66E-045.03E-012690ADCY2,ADCY3,ADCY5,ADCY7,ADRB1,ADCY4,ITGA10,ITGA8,CACNA1C,CACNA2D1,CACNB3,CACNB4,CACNA2D2,DES,ITGA3,ITGA9,LAMA2,MYH6,MYL3,ITGA11,SGCA,SGCB,SGCG,CACNA2D3,TGFB1,TPM2