Fig. 1
From: Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
a Volcano plot of significantly altered genes from the RNA-seq analysis on n = 11 non-neurological disease controls, n = 14 ALS cases (sporadic and C9-ALS). The primary X axis shows the log2 (fold change) of controls vs ALS, while the secondary axis designates the −log10 (p value), analyzed with the following parameters (adjusted p-values (p < 0.05), a fold change greater than 2, and a baseMean value greater than 20). The red dots mark data points that are significantly altered in either direction. Relaxed analysis parameters were used for pathway analysis (adjusted p-values (p < 0.1), a fold change greater than 1.5, and a baseMean value greater than 20) and pie graphs and tables visualizing the gene ontology (GO) distribution of genes detected in both control and ALS groups classified by using Panther terms for biological processes b and molecular functions c