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Table 3 Demographic data of clinical cases, diagnoses and pathologic findings

From: Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

 

Age

Gender

Primary Diagnosis

Secondary Diagnosis

Thal Phase (A score)

Braak stage (B score)

CERAD (C score)

AD

78

female

ADNC, high

CAA

4 (A3)

VI (B3)

frequent (C3)

AD

64

female

ADNC, high

CAA

4 (A3)

VI (B3)

frequent (C3)

AD

77

male

ADNC, high

ARTAG; CAA

4 (A3)

VI (B3)

moderate (C2)

AD

64

male

ADNC, high

CAA

5 (A3)

VI (B3)

frequent (C3)

AD

68

male

LBD (neocortical)

ADNC, intermediate

3 (A2)

V (B3)

frequent (C3)

DLB

81

female

ADNC, high

LBD (neocortical); CAA

4 (A3)

VI (B3)

frequent (C3)

DLB

68

female

LBD (neocortical)

ADNC, high; CAA; LATE stage1

5 (A3)

V (B3)

frequent (C3)

DLB

83

male

ADNC, intermediate

LBD (neocortical); CAA; LATE stage 2

3 (A2)

V (B3)

frequent (C3)

PSP

63

female

FTLD-tau (PSP)

 

0 (A0)

0 (B0)

none (C0)

PSP

69

female

FTLD-tau (PSP)

ADNC, low

3 (A2)

III (B2)

none (C0)

PSP

72

female

FTLD-tau (PSP)

PART (Braak II)

0 (A0)

II (B1)

none (C0)

PSP

78

male

FTLD-tau (PSP)

 

0 (A0)

0 (B0)

none (C0)

PSP

77

male

FTLD-tau (PSP)

ADNC, low; CAA

2 (A1)

II (B1)

none (C0)

CBD

73

female

FTLD-tau (CBD)

ADNC, low; CAA

1 (A1)

II (B1)

none (C0)

CBD

70

male

FTLD-tau (CBD)

ADNC, low; CAA

3 (A2)

II (B1)

none (C0)

  1. Primary neuropathologic diagnoses were based on current guidelines for Alzheimer’s disease neuropathologic change (ADNC) [59], dementia with Lewy Bodies (DLB) [55], and frontotemporal lobar dementia-tau (FTLD-tau) pathology [52], including progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) [20]. Additionally, secondary neuropathologic changes were determined following guidelines for cerebral amyloid angiopathy (CAA) [13], Aging-related tau astrogliopathy (ARTAG) [48], and limbic-predominant age-related TDP-43 encephalopathy (LATE) [64]