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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

Fig. 6

3G12 anti-tau pSer208 immunoreactivity for tau AD pathological inclusions compared to other phospho-tau specific antibodies with adjacent epitopes. Representative images of (a) NFT, (b) neuritic plaques, and (c) neuropil threads in the hippocampal formation of an AD patient with monoclonal antibodies AT8, CP13, 7F2 and 3G12. Scale bars represent 50 μm. (d) Quantification of percent of mature tangles over tau positive neurons stained by AT8 and 3G12 antibodies. Clear circles show individual data points. Error bars show 95% confidence intervals as represented by red bars. e Quantification of neuritic plaques stained by AT8 and 3G12. f Scoring of neuropil threads between AT8 and 3G12 staining

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