From: A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease
sCJD subtypea; Prevalence (%) | Histopathological phenotype | WB resPrPD Profile |
---|---|---|
MV2K; ~ 8 | SD pseudo-laminar in CC (Fig. 1a-d); kuru pl. in Cbl. IHC: fine punctate in CC; Cbl (Fig. 1a-d) | Type 2 (19 kDa) + Type ~ 1 (20 kDa) |
MV2C; ~ 2 | SD: large confluent vacuoles mostly in CC. IHC: co-distributing with SD (Fig. 1e-h). | Type 2 (19 kDa) |
MV1; 5 | SD with fine vacuoles predominantly in CC; IHC: fine punctate pattern in SD regions; in Cbl “brushstroke” pattern (Fig. 1s-u) | Type 1 (21 kDa) |
VV2; 15 | SD like MV2K in CC; no kuru plaques but plaque-like aggregates in Cbl (Not shown) | Type 2 (19 kDa) |
MM2; 4 | As MV2C (Fig. 1i-l) | Similar but not identical to MV2C |
MM1; 64 | As MV1 (Fig. 1v-x) | As MV1 |