Skip to main content

Table 3 Primary motor cortex and spinal cord single-IHC results

From: Quantitative patterns of motor cortex proteinopathy across ALS genotypes

  Primary motor cortex Spinal cord
Anterior horn Corticospinal tract
Genotype n = Statistic Positive pixel count/3mm2 Positive cell count/3mm2 Neuron size (μm2) PPC/2.25mm2 PCC/2.25mm2 Positive cell count/1.75mm2
pTDP-43 p62 CD68 (GMb) CD68 (WMc) pTDP-43 CD68 CD68
Control 11 Mean 139.0 164.3 399.4 2163.0 271.2 140.3
95% CIa 76.0–254.0 93.2–289.6 226.6–703.8 1429.0–2897.0 174.3–421.9 90.1–218.3
Sporadic 19 Mean 14,662.3 989.3 707.7 1613.6 763.9 11,626.9 1104.5 993.6
95% CI 9088.2–23,655.1 653.4–1497.9 477.6–1048.5 1089.1–2390.7 495.5–1032.0 7612.5–17,758.1 850.5–1434.3 765.1–1290.4
C9ORF72 16 Mean 7143.1 1020.8 389.3 1353.8 794.9 10,068.0 1228.3 1179.0
95% CI 4300.9–11,863.4 649.6–1604.1 253.8–597.2 882.6–2076.5 494.4–1095.0 6346.1–15,972.9 917.1–1645.0 880.3–1579.0
SOD1 11 Mean 186.1 123.6 366.0 469.5 987.3 837.7
95% CI 107.8–321.0 73.9–206.8 219.0–611.9 258.1–681.0 694.1–1404.4 588.9–1191.6
FUS 9 Mean 264.1 471.0 490.0 404.4 1489.1 782.0
95% CI 144.5–482.7 267.3–829.9 278.1–863.4 190.9–618.0 1008.7–2198.3 529.7–1154.5
CHMP2B 2 Mean 259.5 229.0 188.5 382.5 217.5 5673.0 1251.0 679.0
95% CI 71.38–363.6
TARDBP 1 Mean 2970.0 144.0 205.0 910.0 853.0 7779.0 881.5 649.0
95% CI
HNRNPA1 1 Mean 463.0 142.0 305.0 547.0 325.0 10,975.0 2149.0 1189.0
95% CI
OPTN 1 Mean 40,668.0 3514.0 383.0 1954.0 1363.0 1649.0 28.5 85.0
95% CI
  1. aConfidence interval; bGrey matter; cWhite matter; ppc = positive pixel count; pcc = positive cell count
\