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Table 3 Primary motor cortex and spinal cord single-IHC results

From: Quantitative patterns of motor cortex proteinopathy across ALS genotypes

 

Primary motor cortex

Spinal cord

Anterior horn

Corticospinal tract

Genotype

n =

Statistic

Positive pixel count/3mm2

Positive cell count/3mm2

Neuron size (μm2)

PPC/2.25mm2

PCC/2.25mm2

Positive cell count/1.75mm2

pTDP-43

p62

CD68 (GMb)

CD68 (WMc)

pTDP-43

CD68

CD68

Control

11

Mean

–

139.0

164.3

399.4

2163.0

–

271.2

140.3

95% CIa

–

76.0–254.0

93.2–289.6

226.6–703.8

1429.0–2897.0

–

174.3–421.9

90.1–218.3

Sporadic

19

Mean

14,662.3

989.3

707.7

1613.6

763.9

11,626.9

1104.5

993.6

95% CI

9088.2–23,655.1

653.4–1497.9

477.6–1048.5

1089.1–2390.7

495.5–1032.0

7612.5–17,758.1

850.5–1434.3

765.1–1290.4

C9ORF72

16

Mean

7143.1

1020.8

389.3

1353.8

794.9

10,068.0

1228.3

1179.0

95% CI

4300.9–11,863.4

649.6–1604.1

253.8–597.2

882.6–2076.5

494.4–1095.0

6346.1–15,972.9

917.1–1645.0

880.3–1579.0

SOD1

11

Mean

–

186.1

123.6

366.0

469.5

–

987.3

837.7

95% CI

–

107.8–321.0

73.9–206.8

219.0–611.9

258.1–681.0

–

694.1–1404.4

588.9–1191.6

FUS

9

Mean

–

264.1

471.0

490.0

404.4

–

1489.1

782.0

95% CI

–

144.5–482.7

267.3–829.9

278.1–863.4

190.9–618.0

–

1008.7–2198.3

529.7–1154.5

CHMP2B

2

Mean

259.5

229.0

188.5

382.5

217.5

5673.0

1251.0

679.0

95% CI

–

–

–

–

71.38–363.6

–

–

–

TARDBP

1

Mean

2970.0

144.0

205.0

910.0

853.0

7779.0

881.5

649.0

95% CI

–

–

–

–

–

–

–

–

HNRNPA1

1

Mean

463.0

142.0

305.0

547.0

325.0

10,975.0

2149.0

1189.0

95% CI

–

–

–

–

–

–

–

–

OPTN

1

Mean

40,668.0

3514.0

383.0

1954.0

1363.0

1649.0

28.5

85.0

95% CI

–

–

–

–

–

–

–

–

  1. aConfidence interval; bGrey matter; cWhite matter; ppc = positive pixel count; pcc = positive cell count