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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Quantitative patterns of motor cortex proteinopathy across ALS genotypes

Fig. 3

Spatial and morphological distribution of proteinopathy across genotypes in the ALS primary motor cortex. Sporadic ALS exhibits NCI and oligodendroglial pathology across layers I-VI as well as the subcortical white matter (a-d). The distribution pattern of pTDP-43 pathology was not entirely dissimilar between sporadic and C9-ALS (e-f), although there was a slight preponderance towards oligodendrocyte inclusions in C9 cases (Fig. 6g and h). FUS mutation cases demonstrated infrequent, compact p62-positive NCI with occasional granular inclusions, as well as occasional oligodendroglial pathology (i-l). SOD1 mutation cases, by contrast, exhibited granular p62 staining confined to the middle cortical layers with infrequent NCI in layer V, without obvious glial pathology. Arrows highlight respective proteinopathy. Scale bar applicable to all panels = 50 μm

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