Fig. 7

Recovery of motor function with iNSC transplantation. a: Experimental timeline for functional assessment after iNSC (or vehicle) injection. After 12 weeks of CPZ, mice were returned to normal chow with intracerebral injection performed the following day and exposure to Miss-step wheels the next day. Miss-step wheels with irregularly spaced rungs present a motor skill task mice must learn to run rapidly (week 1); the subsequent plateau velocity reveals deficits of bilateral sensorimotor function (week 2). b-c: The average velocities (b) and the maximum velocities (c) show deficits in vehicle-injected CPZ mice during the learning phase that reach statistical significance during the plateau phase, as compared to naïve mice. CPZ mice injected with iNSCs show recovery in that both average and maximum velocities are not significantly different from the naïve mice. Velocity measures were compared using two-way ANOVA with Sidak’s multiple comparison test. Data are mean values ± sem. Data from 3 independent cohorts was combined for analysis of naïve (n = 11), CPZ vehicle (n = 12), and CPZ iNSC (n = 11)