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Table 2 Transgenic AD-like mouse models in which pSer8Aβ and npAβ deposition has been analyzed. APP, Amyloid precursor protein; PS1, Presenilin-1; h-human; m-mouse; Swe, Swedish; Ind, Indiana; Lon, London; PSEN1, Presenilin-1; KI, Knock-in; Tg, Transgenic; Ref, Reference

From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Mouse model Transgene Ref. Transgenic
promoter
Age (months) Amyloid plaques CAA lesions
npAβ pSer8Aβ npAβ pSer8Aβ
APP Transgenics:
 J20 hAPP770 48 PDGFβ 4 (n = 4) + No No
(K670N/M671L; V717F)    8 (n = 4) ++ + Yes Yes
Swe; Ind mutation    16 (n = 3) ++++ +++ Yes Yes
 hAPP751 hAPP751 49 mouse Thy-1 14 (n = 2) ++++ +++ Yes Yes
(K670N/M671L; V717I)        
Swe; Lon mutation        
 TgSwDI hAPP770 50 mouse Thy-1 3 (n = 4) + + Yes Yes
(K670N/M671L; E693Q; D694N)    6 (n = 2) ++ + Yes Yes
    12 (n = 4) +++ ++ Yes Yes
Swe; Dutch; Iowa mutation    24 (n = 4) ++++ +++ Yes Yes
APP/PS1 Transgenics:
 APP/PS1ΔE9 m/hAPP695 51 mouse PrnP 6 (n = 4) ++ + Yes Yes
(K595N/M596L);    17 (n = 3) +++ ++ Yes Yes
hPS1 deletion of exon 9    24 (n = 4) ++++ +++ Yes Yes
Swe; PSEN1ΔE9        
 PS/APP hAPP695
hPS1 (M146L)
Swe; PS1M146L
52 Hamster PrnP (APP)
PDGFβ (PS1)
18 (n = 5) ++++ +++ Yes Yes
APP/PS1/Tau Transgenics:
 3xTg-AD hAPP695 (K670N/M671L); hPS1 (M146V); TauP301L
Swe;PS1M146V;MAPT4R0N (P301L)
53 mouse Thy-1.2 (APP, Tau) PS1 KI 5 (n = 4) ++ + No No
14 (n = 3) +++ ++ Yes Yes
27 (n = 4) ++++ +++ Yes Yes
  1. The following semi-quantitative scoring criteria were used: -, no plaque staining, +, 1–5 plaques; ++, 6–10 plaques; +++, 11–100 plaques; ++++, > 100 plaques. Abbreviations: Ref References; Swe Swedish; Ind Indiana; Lon London; PS1 presenelin-1, MAPT, microtubule-associated protein tau; PDGFβ platelet-derived growth factor B-chain; PrnP prion protein; KI, knock-in
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