From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
Mouse model | Transgene | Ref. | Transgenic promoter | Age (months) | Amyloid plaques | CAA lesions | ||
---|---|---|---|---|---|---|---|---|
npAβ | pSer8Aβ | npAβ | pSer8Aβ | |||||
APP Transgenics: | ||||||||
J20 | hAPP770 | 48 | PDGFβ | 4 (n = 4) | + | – | No | No |
(K670N/M671L; V717F) | 8 (n = 4) | ++ | + | Yes | Yes | |||
Swe; Ind mutation | 16 (n = 3) | ++++ | +++ | Yes | Yes | |||
hAPP751 | hAPP751 | 49 | mouse Thy-1 | 14 (n = 2) | ++++ | +++ | Yes | Yes |
(K670N/M671L; V717I) | ||||||||
Swe; Lon mutation | ||||||||
TgSwDI | hAPP770 | 50 | mouse Thy-1 | 3 (n = 4) | + | + | Yes | Yes |
(K670N/M671L; E693Q; D694N) | 6 (n = 2) | ++ | + | Yes | Yes | |||
12 (n = 4) | +++ | ++ | Yes | Yes | ||||
Swe; Dutch; Iowa mutation | 24 (n = 4) | ++++ | +++ | Yes | Yes | |||
APP/PS1 Transgenics: | ||||||||
APP/PS1ΔE9 | m/hAPP695 | 51 | mouse PrnP | 6 (n = 4) | ++ | + | Yes | Yes |
(K595N/M596L); | 17 (n = 3) | +++ | ++ | Yes | Yes | |||
hPS1 deletion of exon 9 | 24 (n = 4) | ++++ | +++ | Yes | Yes | |||
Swe; PSEN1ΔE9 | ||||||||
PS/APP | hAPP695 hPS1 (M146L) Swe; PS1M146L | 52 | Hamster PrnP (APP) PDGFβ (PS1) | 18 (n = 5) | ++++ | +++ | Yes | Yes |
APP/PS1/Tau Transgenics: | ||||||||
3xTg-AD | hAPP695 (K670N/M671L); hPS1 (M146V); TauP301L Swe;PS1M146V;MAPT4R0N (P301L) | 53 | mouse Thy-1.2 (APP, Tau) PS1 KI | 5 (n = 4) | ++ | + | No | No |
14 (n = 3) | +++ | ++ | Yes | Yes | ||||
27 (n = 4) | ++++ | +++ | Yes | Yes |