Skip to main content

Table 2 Transgenic AD-like mouse models in which pSer8Aβ and npAβ deposition has been analyzed. APP, Amyloid precursor protein; PS1, Presenilin-1; h-human; m-mouse; Swe, Swedish; Ind, Indiana; Lon, London; PSEN1, Presenilin-1; KI, Knock-in; Tg, Transgenic; Ref, Reference

From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Mouse model

Transgene

Ref.

Transgenic

promoter

Age (months)

Amyloid plaques

CAA lesions

npAβ

pSer8Aβ

npAβ

pSer8Aβ

APP Transgenics:

 J20

hAPP770

48

PDGFβ

4 (n = 4)

+

No

No

(K670N/M671L; V717F)

  

8 (n = 4)

++

+

Yes

Yes

Swe; Ind mutation

  

16 (n = 3)

++++

+++

Yes

Yes

 hAPP751

hAPP751

49

mouse Thy-1

14 (n = 2)

++++

+++

Yes

Yes

(K670N/M671L; V717I)

       

Swe; Lon mutation

       

 TgSwDI

hAPP770

50

mouse Thy-1

3 (n = 4)

+

+

Yes

Yes

(K670N/M671L; E693Q; D694N)

  

6 (n = 2)

++

+

Yes

Yes

   

12 (n = 4)

+++

++

Yes

Yes

Swe; Dutch; Iowa mutation

  

24 (n = 4)

++++

+++

Yes

Yes

APP/PS1 Transgenics:

 APP/PS1ΔE9

m/hAPP695

51

mouse PrnP

6 (n = 4)

++

+

Yes

Yes

(K595N/M596L);

  

17 (n = 3)

+++

++

Yes

Yes

hPS1 deletion of exon 9

  

24 (n = 4)

++++

+++

Yes

Yes

Swe; PSEN1ΔE9

       

 PS/APP

hAPP695

hPS1 (M146L)

Swe; PS1M146L

52

Hamster PrnP (APP)

PDGFβ (PS1)

18 (n = 5)

++++

+++

Yes

Yes

APP/PS1/Tau Transgenics:

 3xTg-AD

hAPP695 (K670N/M671L); hPS1 (M146V); TauP301L

Swe;PS1M146V;MAPT4R0N (P301L)

53

mouse Thy-1.2 (APP, Tau) PS1 KI

5 (n = 4)

++

+

No

No

14 (n = 3)

+++

++

Yes

Yes

27 (n = 4)

++++

+++

Yes

Yes

  1. The following semi-quantitative scoring criteria were used: -, no plaque staining, +, 1–5 plaques; ++, 6–10 plaques; +++, 11–100 plaques; ++++, > 100 plaques. Abbreviations: Ref References; Swe Swedish; Ind Indiana; Lon London; PS1 presenelin-1, MAPT, microtubule-associated protein tau; PDGFβ platelet-derived growth factor B-chain; PrnP prion protein; KI, knock-in