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Table 1 Examination summary of aged control (AC), Alzheimer’s disease (AD) and Down syndrome (DS) brains

From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Cases Age (years) Gender Brain region examined 82E1
(Aβ1-x)
7H3D6 (npAβ) 1E4E11 (pSerAβ) PMI (hours) Brain weight (grams) Cause of Death Braak Stage
Aged Control (AC)
AC-1 72 Female F NA 1300 Cardiac arrest NA
    HC + + (+)   
AC-2 53 Male F 9 1500 Cardiac arrest NA
    HC +   
AC-3 60 Female F +++ 11 1150 Cardiac arrest; Sepsis NA
    O +++   
AC-4 64 Male HC +++ + 9.5 1380 Congestive heart failure NA
AC-5 70 Male F ++ + (+) 17 1500 Mesothelia carcinoma NA
    HC +++ + +   
AC-6 60 Female F ++ 3.5 1380 COPD; AS NA
    HC ++   
AC-7 87 Female F +++ + (+) NA NA Choking NA
    T/HC    
AC-8 74 Male F ++ NA 1400 Dead on Arrival NA
Alzheimer’s Disease (AD)
AD-1 82 Female F ++++ + ++ 16 900 Pneumonia NA
    HC +++ + ++   
AD-2 79 Female F +++ ++ + 13 1040 AD; AS NA
    HC +++ + ++   
AD-3 91 Female T ++ + 3.5 1370 Pneumonia; AD; AS; Lacunar infarct III -IV
    HC +++ + ++   
AD-4 71 Male F +++ + ++ 36 NA AD; AS NA
    HC +++ + ++   
AD-5 84 Female F +++ ++ NA 1000 AD; AS; Binswanger NA
    T ++ ++   
AD-6 92 Female HC +++ + ++ 7 1210 AD; AS; Infarct NA
AD-7 78 Male F +++ + ++ 18 1200 AD; AS V-VI
    HC ++ +   
AD-8 96 Female F ++ ++ ++ 21 1050 AD; AS; Infarct NA
    HC +++ + ++   
AD-9 78 Male P + ++ + NA 1180 AD; Subdural hematoma V-VI
    T/HC +++ +++ +   
AD-10 88 Female P +++ + + 24 1220 AD; AS  
    HC F ++++ ++ +++   
AD-11 84 Female F +++ ++ 16.5 1110 AD; AS; DLBD NA
    HC +++ + ++   
AD-12 88 Female F +++ + + 24 1050 AD; AS; Infarct V-VI
    HC ++ ++ +   
Down syndrome (DS)
DS-1 47 Male F ++++ + ++ 34 910 Glioblastoma; AD NA
    T/HC ++++ + ++   
DS-2 55 Male F ++++ ++ ++ NA 1040 Pneumonia; AD NA
    T ++++ ++ +++   
DS-3 46 Female T/HC +++ ++ ++ 18 870 Pneumonia; AD NA
  1. The following semi-quantitative scoring criteria were used: –, no staining; (+), 1–10 plaques; +, 11–30 plaques; ++, 31–50 plaques; +++, 51–100 plaques, and ++++, > 100 plaques per cm2. F frontal; HC hippocampal; T temporal; O occipital; P parietal; DLBD Diffuse Lewy Body Disease; COPD Chronic Obstructive Pulmonary Disease; AS Arteriolar sclerosis; NA not available
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