Table 1 Examination summary of aged control (AC), Alzheimer’s disease (AD) and Down syndrome (DS) brains
From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
Cases | Age (years) | Gender | Brain region examined | 82E1 (Aβ1-x) | 7H3D6 (npAβ) | 1E4E11 (pSerAβ) | PMI (hours) | Brain weight (grams) | Cause of Death | Braak Stage |
|---|---|---|---|---|---|---|---|---|---|---|
Aged Control (AC) | ||||||||||
AC-1 | 72 | Female | F | – | – | – | NA | 1300 | Cardiac arrest | NA |
HC | + | + | (+) | |||||||
AC-2 | 53 | Male | F | – | – | – | 9 | 1500 | Cardiac arrest | NA |
HC | + | – | – | |||||||
AC-3 | 60 | Female | F | +++ | – | – | 11 | 1150 | Cardiac arrest; Sepsis | NA |
O | +++ | – | – | |||||||
AC-4 | 64 | Male | HC | +++ | + | – | 9.5 | 1380 | Congestive heart failure | NA |
AC-5 | 70 | Male | F | ++ | + | (+) | 17 | 1500 | Mesothelia carcinoma | NA |
HC | +++ | + | + | |||||||
AC-6 | 60 | Female | F | ++ | – | – | 3.5 | 1380 | COPD; AS | NA |
HC | ++ | – | – | |||||||
AC-7 | 87 | Female | F | +++ | + | (+) | NA | NA | Choking | NA |
T/HC | – | – | – | |||||||
AC-8 | 74 | Male | F | ++ | – | – | NA | 1400 | Dead on Arrival | NA |
Alzheimer’s Disease (AD) | ||||||||||
AD-1 | 82 | Female | F | ++++ | + | ++ | 16 | 900 | Pneumonia | NA |
HC | +++ | + | ++ | |||||||
AD-2 | 79 | Female | F | +++ | ++ | + | 13 | 1040 | AD; AS | NA |
HC | +++ | + | ++ | |||||||
AD-3 | 91 | Female | T | ++ | + | – | 3.5 | 1370 | Pneumonia; AD; AS; Lacunar infarct | III -IV |
HC | +++ | + | ++ | |||||||
AD-4 | 71 | Male | F | +++ | + | ++ | 36 | NA | AD; AS | NA |
HC | +++ | + | ++ | |||||||
AD-5 | 84 | Female | F | +++ | – | ++ | NA | 1000 | AD; AS; Binswanger | NA |
T | ++ | ++ | – | |||||||
AD-6 | 92 | Female | HC | +++ | + | ++ | 7 | 1210 | AD; AS; Infarct | NA |
AD-7 | 78 | Male | F | +++ | + | ++ | 18 | 1200 | AD; AS | V-VI |
HC | ++ | – | + | |||||||
AD-8 | 96 | Female | F | ++ | ++ | ++ | 21 | 1050 | AD; AS; Infarct | NA |
HC | +++ | + | ++ | |||||||
AD-9 | 78 | Male | P | + | ++ | + | NA | 1180 | AD; Subdural hematoma | V-VI |
T/HC | +++ | +++ | + | |||||||
AD-10 | 88 | Female | P | +++ | + | + | 24 | 1220 | AD; AS | |
HC F | ++++ | ++ | +++ | |||||||
AD-11 | 84 | Female | F | +++ | – | ++ | 16.5 | 1110 | AD; AS; DLBD | NA |
HC | +++ | + | ++ | |||||||
AD-12 | 88 | Female | F | +++ | + | + | 24 | 1050 | AD; AS; Infarct | V-VI |
HC | ++ | ++ | + | |||||||
Down syndrome (DS) | ||||||||||
DS-1 | 47 | Male | F | ++++ | + | ++ | 34 | 910 | Glioblastoma; AD | NA |
T/HC | ++++ | + | ++ | |||||||
DS-2 | 55 | Male | F | ++++ | ++ | ++ | NA | 1040 | Pneumonia; AD | NA |
T | ++++ | ++ | +++ | |||||||
DS-3 | 46 | Female | T/HC | +++ | ++ | ++ | 18 | 870 | Pneumonia; AD | NA |