Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Fig. 2

Age-dependent deposition of cerebral npAβ and pSer8Aβ in J20 mice. Brain sections of 4, 8, and 16 month-old mice were immunolabeled with npAβ (a, c and e) and pSer8Aβ-specific (b, d and f) antibodies. npAβ deposits were detected initially in the hippocampus at 4 months (a). A faint reactivity of pSer8Aβ was seen in extracellular amyloid deposits and in some vessels in the hippocampus (b; inset). By 8 months, npAβ (c) and pSer8Aβ deposition (d) extended to the neocortex as compact and diffuse deposits. By 16 months, more intense and abundant npAβ (e) and pSer8Aβ-immunoreactivity (f) was observed in extracellular plaques (arrows) and blood vessels (arrowheads) affected by CAA (inset in panel f). Sub, subiculum; DG, dentate gyrus; DGm, dentate gyrus molecular layer. Scale bar = 200 μm. Insets show the magnified areas indicated by the boxes. Scale bar = 50 μm

Back to article page
\