Fig. 1
From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
Immunohistochemical detection of pSer8Aβ peptides in DS and AD brains. Immunohistochemical staining was performed on adjacent serial paraffin sections with monoclonal antibodies 82E1 (Aβ1-x), 7H3D6 (non-phoshoAβ) and 1E4E11 (pSer8Aβ). Asp-1 Aβ (Aβ1-x), npAβ and pSer8Aβ species colocalized in DS (d-f) and AD (g-i) hippocampus. pSer8Aβ and npAβ were detected in extracellular Aβ plaques in DS and AD brains. AC brains showed some immunoreactivity with 82E1antibody (a), but very limited if any reactivity with antibodies 7H3D6 (b) and 1E4E11 (c). Scale bar = 100 μM