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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes

Fig. 6

Variable spongiform change and amyloid plaque deposition in the brains of tg66 mice inoculated with sporadic or iatrogenic cases of MV2K CJD. a H&E staining of a tg66 mouse inoculated with MV2K sCJD case 7 (386 dpi). The black arrows indicate eosinophilic amyloid plaques. The neuropathological features of case 10 were identical to those of case 7. b H&E staining of tg66 mice inoculated with MV2K iCJD cases 19 (185 dpi, left column) and 20 (458 dpi, right column). No eosinophilic amyloid plaques are detectable in any of the brain regions shown. The neuropathological features of case 18 were the same as those of case 19. The mean percentage of PrPSc-M129 in each sample is given under the case number. The brain regions shown are indicated on the left. For all panels, scale bar = 50 μm

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