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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

Fig. 2

Confocal microscopy and ultrastructural imaging of early endosomes in fibroblasts from individuals with DS. a Representative images of EEA1-positive early endosomes (green) in fibroblasts from euploid individuals and individuals with DS; b Quantification of EEA1-positive puncta volume from confocal microscopy images of fibroblasts, showing a significantly increased volume of early endosome in DS condition (mixed effect ANOVA, genotype *p-value = 0.03); c EEA1-positive puncta number normalized to ROI area is not significantly different between euploid and DS fibroblasts in confocal microscopy (mixed effect ANOVA, ns, genotype p-value = 0.73); d-g Electron micrographs of EEA1 immunoperoxidase-labelled fibroblasts from a euploid individual (d squared zone magnified in (e)) and an individual with DS (f squared zone magnified in (g)) after chemical fixation

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