Fig. 1
From: Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome
Ultrastructural imaging of early endosomes in LCLs from individual with DS. a, b Electron micrograph representing EEA1 immunoperoxidase-labelled early endosomes in a LCL from a euploid individual. The squared zone in (a) is magnified in (b); c, d 2 serial TEM sections of an EEA1 immunoperoxidase-labelled cluster of early endosomes in a trisomic lymphoblastoid cell; e, f 2 clusters of early endosomes in a lymphoblastoid cell from an individual with DS. The pseudo-colored red halo suggests the extent of labelled area as it should appear with confocal analysis. The squared zone in (c) is enlarged in (d); g Quantification of early endosomal area in LCLs imaged by TEM, showing no significant difference in mean early endosomal area between LCLs from euploid individual and individual with DS (mixed effects ANOVA, genotype, p-value = 0.57)