Fig. 4
Expression of SYNJ1 mRNA in human post-mortem AD brains. a qPCR for SYNJ1 was performed on the mRNA extracted from control (n = 30) and AD (n = 36) T1 isocortex. The level of normalized SYNJ1 mRNA was significantly increased in AD brains. Two FAD cases are shown in red. b No significant difference was observed in the normalised SYNJ1 mRNA levels between non-carriers (n = 15) and carriers (n = 4) of APOEε4 allele(s) in the control cohort. c In AD cohorts, SYNJ1 mRNA level was significantly higher in APOEε4 carriers (n = 21) than in non-carriers (n = 14). FAD cases are shown in red. *p < 0.05, **p < 0.01, by unequal variances t test. d There was a significant correlation between the levels of SYNJ1 mRNA and phosphorylated tau detected by WB using PHF1. (r2 = 0.3713, n = 66, p = 0.0021, by Pearson correlation test)