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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer’s disease

Fig. 2

Detection of SYNJ1 immunoreactivities in intraneuronal granular structures in AD brains. a-l Double immunostaining for SYNJ1 (a, d, g, j, green) and PHF1 (b, e, h, k, red) shows that SYNJ1 immunoreactivity is detected as a perinuclear rim and in the perikarya in non-tangle bearing neurons (a-c) and in tangle bearing neurons (d-l) in the CA1–2 pyramidal neurons of AD hippocampus. SYNJ1-positive intraneuronal granular or donuts-like structures (g, inset) were occasionally detected in tangle bearing neurons and were surrounded and sometimes overlapped with hyperphosphorylated tau in NFTs (l, arrowhead). Representative images of an APOEε3/3 AD case are shown. Scale bars 10 μm

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