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Table 1 Overview of the pediatric tumor patients with detailed information on age, sex, radiotherapy, histology, localization, metastasis and dosage

From: Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients

DrugPatient #AgeSexRTXTumor histologyLocalizationLepto-meningeal metastasisDose mg/kg
Imatinib118,3mfocalGerm cell tumorpinealyes8.51 BID
214.5ffocalGlioblastomahemisphericyes1.82 QD
37.5mCSIPlexuscarcinomahemisphericyes16.67 QD
Dasatinib119.1mfocalGerm cell tumorpinealyes1.72 BID
Nintedanib419.4mfocalEpendymomahemisphericyes3.72 BID
513.5mfocalEpendymomahemisphericno3.23 BID
67.6mfocalEpendymomaposterior fossayes10.35 QD
Panobinostat420.3mfocalEpendymomahemisphericyes0.35 3 doses / week
Regorafenib420.1mfocalEpendymomahemisphericyes0.78 QD
Ribociclib78.4ffocalEpithelioid sarcoma (metastasis)non CNS primaryyes3.33 QD
Vorinostat810.8mCSIMedulloblastomaposterior fossayes3.74 QD
912.7fCSIAtypical teratoid rhabdoid tumorhemisphericyes2.63 QD
  1. RTX, radiotherapy; CSI, craniospinal irradiation; CNS, central nervous system