Fig. 3

RNA-sequencing analysis demonstrates that native hepatocytes drive the transcriptomic signature of meningioma liver metastasis. a Hierarchical clustering of the top 2000 most variable genes segregates the meningioma liver metastasis from the intracranial samples. b, c Gene ontology analysis of increased transcripts in intracranial meningioma samples shows (b) enrichment for SUZ12 and FOXM1 transcription factor pathways and (c) mitotic spindle function. d Gene ontology analysis of increased transcripts in the meningioma liver metastasis shows enrichment for liver specific processes, such as monocarboxylic acid transport, fatty acid processing, and LDL remodeling. e Analysis of tissue specific expression patterns demonstrates that gene sets enriched in the meningioma liver metastasis have liver-specific expression patterns