Fig. 2

DNA methylation analysis reveals minimal contamination, conserved epigenetic classification, and concordant copy number variants in meningioma liver metastasis. a Hierarchical clustering of the top 2000 most variable DNA methylation probes segregates the liver metastasis from the intracranial meningioma samples. b Cell type deconvolution demonstrates ~ 10% hepatocyte composition within the liver metastasis, which is not identified in the intracranial samples. c Tumor purity analysis reveals no significant difference between intracranial and liver metastasis samples. d Random forest classification correctly identifies all six intracranial sites and the liver metastasis as meningioma with high confidence (classifier score = 0.99 for all samples). e Copy number variant (CNV) profiles show no significant private alterations in the liver metastasis compared to intracranial samples