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Table 3 Top results of the functional module discovery analysis using the DEGs identified in MSA-C

From: Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

CLUSTER (Genes)TERMNAMEGOIDQ VALUEGENE COUNTTERMGENES
M1 (152)amyloid-beta formationGO:00342055.3E-056ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP
amyloid precursor protein catabolic processGO:00429871.0E-046ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP
amyloid-beta metabolic processGO:00504351.0E-046ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP
amyloid precursor protein metabolic processGO:00429822.8E-046ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP
amyloid fibril formationGO:19900001.0E-034CLU,GSN,APP,PSEN1
M2 (85)NADH dehydrogenase complex assemblyGO:00102578.2E-034NDUFA1,NDUFS5,NDUFB3,NDUFB5
mitochondrial respiratory chain complex I assemblyGO:00329818.2E-034NDUFA1,NDUFS5,NDUFB3,NDUFB5
mitochondrion organizationGO:00070051.6E-027SLC25A5,NDUFB3,NDUFB5,PARP1,PSMD10,NDUFS5,NDUFA1
mitochondrial respiratory chain complex assemblyGO:00331081.8E-024NDUFA1,NDUFS5,NDUFB3,NDUFB5
negative regulation of centriole replicationGO:00466002.0E-022RBM14,CHMP2A
M3 (117)regulation of cellular protein localizationGO:19038271.1E-029EZR,IWS1,RDX,GPSM2,NUMB,PICALM,RTN4,BAG3,UHMK1
regulation of organelle assemblyGO:19021151.4E-026STAG1,EZR,CCP110,GPSM2,RDX,CHMP5
sulfur compound biosynthetic processGO:00442721.7E-024MTRR,GCLC,MAT2A,PAPSS1
membrane dockingGO:00224061.8E-023PDZD8,EZR,ATG14
regulation of protein export from nucleusGO:00468252.3E-023BAG3,IWS1,UHMK1
M4 (12)negative regulation of multi-organism processGO:00439011.3E-023IFITM3,TIMP1,ANXA2
regulation of multi-organism processGO:00439002.8E-023IFITM3,TIMP1,ANXA2
negative regulation of protein catabolic processGO:00421773.3E-022TIMP1,ANXA2
skeletal system developmentGO:00015013.9E-022CD44,ANXA2
negative regulation of endopeptidase activityGO:00109514.0E-022CD44,TIMP1
M5 (63)integrin-mediated signaling pathwayGO:00072292.2E-023FLNA,LAMA5,ZYX
positive regulation of cell developmentGO:00107202.8E-024NSMF,FLNA,ARHGEF2,PLXNB2
actin cytoskeleton organizationGO:00300364.0E-025FSCN1,RHOG,FLNA,ZYX,ARHGEF2
actin filament organizationGO:00070154.1E-024FSCN1,FLNA,ARHGEF2,ZYX
supramolecular fiber organizationGO:00974354.1E-025FSCN1,FLNA,ZYX,B4GALT7,ARHGEF2
M6 (10)calcium ion transportGO:00068164.0E-022CDH23,PRKG1
divalent metal ion transportGO:00708384.1E-022CDH23,PRKG1
divalent inorganic cation transportGO:00725114.1E-022CDH23,PRKG1
M7 (164)synapse organizationGO:00508084.4E-023CNTN2,NLGN3,SLITRK1
M8 (24)renal system developmentGO:00720014.7E-022COL4A1,ITGB4
urogenital system developmentGO:00016554.9E-022COL4A1,ITGB4