Table 3 Top results of the functional module discovery analysis using the DEGs identified in MSA-C
CLUSTER (Genes) | TERMNAME | GOID | Q VALUE | GENE COUNT | TERMGENES |
|---|---|---|---|---|---|
M1 (152) | amyloid-beta formation | GO:0034205 | 5.3E-05 | 6 | ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP |
amyloid precursor protein catabolic process | GO:0042987 | 1.0E-04 | 6 | ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP | |
amyloid-beta metabolic process | GO:0050435 | 1.0E-04 | 6 | ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP | |
amyloid precursor protein metabolic process | GO:0042982 | 2.8E-04 | 6 | ROCK2,DYRK1A,CLU,PSEN1,EFNA1,APP | |
amyloid fibril formation | GO:1990000 | 1.0E-03 | 4 | CLU,GSN,APP,PSEN1 | |
M2 (85) | NADH dehydrogenase complex assembly | GO:0010257 | 8.2E-03 | 4 | NDUFA1,NDUFS5,NDUFB3,NDUFB5 |
mitochondrial respiratory chain complex I assembly | GO:0032981 | 8.2E-03 | 4 | NDUFA1,NDUFS5,NDUFB3,NDUFB5 | |
mitochondrion organization | GO:0007005 | 1.6E-02 | 7 | SLC25A5,NDUFB3,NDUFB5,PARP1,PSMD10,NDUFS5,NDUFA1 | |
mitochondrial respiratory chain complex assembly | GO:0033108 | 1.8E-02 | 4 | NDUFA1,NDUFS5,NDUFB3,NDUFB5 | |
negative regulation of centriole replication | GO:0046600 | 2.0E-02 | 2 | RBM14,CHMP2A | |
M3 (117) | regulation of cellular protein localization | GO:1903827 | 1.1E-02 | 9 | EZR,IWS1,RDX,GPSM2,NUMB,PICALM,RTN4,BAG3,UHMK1 |
regulation of organelle assembly | GO:1902115 | 1.4E-02 | 6 | STAG1,EZR,CCP110,GPSM2,RDX,CHMP5 | |
sulfur compound biosynthetic process | GO:0044272 | 1.7E-02 | 4 | MTRR,GCLC,MAT2A,PAPSS1 | |
membrane docking | GO:0022406 | 1.8E-02 | 3 | PDZD8,EZR,ATG14 | |
regulation of protein export from nucleus | GO:0046825 | 2.3E-02 | 3 | BAG3,IWS1,UHMK1 | |
M4 (12) | negative regulation of multi-organism process | GO:0043901 | 1.3E-02 | 3 | IFITM3,TIMP1,ANXA2 |
regulation of multi-organism process | GO:0043900 | 2.8E-02 | 3 | IFITM3,TIMP1,ANXA2 | |
negative regulation of protein catabolic process | GO:0042177 | 3.3E-02 | 2 | TIMP1,ANXA2 | |
skeletal system development | GO:0001501 | 3.9E-02 | 2 | CD44,ANXA2 | |
negative regulation of endopeptidase activity | GO:0010951 | 4.0E-02 | 2 | CD44,TIMP1 | |
M5 (63) | integrin-mediated signaling pathway | GO:0007229 | 2.2E-02 | 3 | FLNA,LAMA5,ZYX |
positive regulation of cell development | GO:0010720 | 2.8E-02 | 4 | NSMF,FLNA,ARHGEF2,PLXNB2 | |
actin cytoskeleton organization | GO:0030036 | 4.0E-02 | 5 | FSCN1,RHOG,FLNA,ZYX,ARHGEF2 | |
actin filament organization | GO:0007015 | 4.1E-02 | 4 | FSCN1,FLNA,ARHGEF2,ZYX | |
supramolecular fiber organization | GO:0097435 | 4.1E-02 | 5 | FSCN1,FLNA,ZYX,B4GALT7,ARHGEF2 | |
M6 (10) | calcium ion transport | GO:0006816 | 4.0E-02 | 2 | CDH23,PRKG1 |
divalent metal ion transport | GO:0070838 | 4.1E-02 | 2 | CDH23,PRKG1 | |
divalent inorganic cation transport | GO:0072511 | 4.1E-02 | 2 | CDH23,PRKG1 | |
M7 (164) | synapse organization | GO:0050808 | 4.4E-02 | 3 | CNTN2,NLGN3,SLITRK1 |
M8 (24) | renal system development | GO:0072001 | 4.7E-02 | 2 | COL4A1,ITGB4 |
urogenital system development | GO:0001655 | 4.9E-02 | 2 | COL4A1,ITGB4 |