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Table 2 Top genes for the different MSA subtypes after p-value combination. Downregulated genes are reported in grey

From: Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

Group

Genes Info

Differential Expression Cohort 1

Differential Expression Cohort 2

Combined p- values

Averaged log2 FC

Symbol

Ensembl ID

Base Mean

log2 (FC)

p

adj p

Base Mean

log2 (FC)

p

adj p

p

adj p

MSA

ACTN1

ENSG00000072110

120.266

1.309

2.3E-06

1.4E-02

152.163

1.055

1.4E-04

2.0E-01

1.2E-07

1.4E-03

1.182

EMP1

ENSG00000134531

59.778

1.636

7.4E-06

1.6E-02

240.880

1.254

7.3E-04

4.9E-01

5.8E-07

3.5E-03

1.445

NFIL3

ENSG00000165030

68.525

1.019

1.1E-04

4.6E-02

21.457

1.567

5.1E-04

4.1E-01

2.4E-06

9.8E-03

1.293

PI15

ENSG00000137558

13.120

1.086

2.3E-02

3.7E-01

11.510

2.273

9.8E-06

5.1E-02

6.0E-06

1.8E-02

1.679

TUBB6

ENSG00000176014

31.136

1.426

4.5E-06

1.5E-02

0.696

1.885

8.8E-02

1.0E+ 00

9.0E-06

2.2E-02

1.656

VIM

ENSG00000026025

297.903

0.701

7.8E-03

2.5E-01

1841.955

1.240

7.0E-05

1.5E-01

1.1E-05

2.2E-02

0.971

COL4A1

ENSG00000187498

94.979

1.424

1.6E-04

5.6E-02

71.659

1.008

4.3E-03

7.6E-01

1.3E-05

2.2E-02

1.216

NFKBIA

ENSG00000100906

280.164

0.672

9.7E-05

4.1E-02

8.006

0.932

8.9E-03

8.8E-01

1.5E-05

2.2E-02

0.802

MAT2A

ENSG00000168906

766.718

0.641

6.1E-03

2.4E-01

1065.143

0.902

1.6E-04

2.0E-01

1.6E-05

2.2E-02

0.771

AEBP1

ENSG00000106624

238.300

1.638

2.1E-06

1.4E-02

14.682

0.328

4.5E-01

1.0E+ 00

1.9E-05

2.2E-02

0.983

MSA-P

GPNMB

ENSG00000136235

87.507

1.798

1.5E-03

3.0E-01

34.116

1.773

2.2E-05

7.7E-02

1.7E-06

2.0E-02

1.785

MSA-C

PGAM2

ENSG00000164708

64.618

1.906

4.7E-04

3.6E-02

230.022

3.193

3.5E-08

4.8E-05

2.7E-08

5.6E-05

2.549

ST5

ENSG00000166444

140.163

1.216

6.0E-07

7.8E-04

79.401

1.146

8.8E-05

6.7E-03

4.8E-08

5.6E-05

1.181

STON1

ENSG00000243244

59.570

1.560

1.1E-03

5.7E-02

433.908

2.177

1.0E-08

2.7E-05

2.3E-08

5.6E-05

1.868

RFTN1

ENSG00000131378

53.043

2.423

7.5E-07

8.6E-04

66.900

1.345

6.2E-05

6.0E-03

4.5E-08

5.6E-05

1.884

ACTN1

ENSG00000072110

101.733

1.939

2.9E-05

9.3E-03

141.214

1.905

5.7E-06

1.5E-03

8.6E-08

7.0E-05

1.922

MMP14

ENSG00000157227

68.018

1.740

1.5E-04

2.0E-02

270.406

2.128

1.2E-06

5.8E-04

9.0E-08

7.0E-05

1.934

ITGB4

ENSG00000132470

425.361

1.491

1.2E-04

1.8E-02

109.863

1.650

6.0E-06

1.5E-03

1.8E-07

1.2E-04

1.570

MAPK4

ENSG00000141639

274.832

1.561

3.6E-09

6.0E-05

53.534

0.402

3.6E-01

6.5E-01

2.9E-07

1.7E-04

0.981

OMG

ENSG00000126861

431.926

−1.384

2.3E-03

8.0E-02

56.937

−2.185

2.5E-06

9.7E-04

6.0E-07

2.3E-04

−1.785

FAM107A

ENSG00000168309

2370.587

0.848

9.9E-03

1.6E-01

2751.910

1.754

3.5E-07

2.7E-04

4.6E-07

2.3E-04

1.301

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Acta Neuropathologica Communications

ISSN: 2051-5960

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