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Table 2 Top genes for the different MSA subtypes after p-value combination. Downregulated genes are reported in grey

From: Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

GroupGenes InfoDifferential Expression Cohort 1Differential Expression Cohort 2Combined p- valuesAveraged log2 FC
SymbolEnsembl IDBase Meanlog2 (FC)padj pBase Meanlog2 (FC)padj ppadj p
MSAACTN1ENSG00000072110120.2661.3092.3E-061.4E-02152.1631.0551.4E-042.0E-011.2E-071.4E-031.182
EMP1ENSG0000013453159.7781.6367.4E-061.6E-02240.8801.2547.3E-044.9E-015.8E-073.5E-031.445
NFIL3ENSG0000016503068.5251.0191.1E-044.6E-0221.4571.5675.1E-044.1E-012.4E-069.8E-031.293
PI15ENSG0000013755813.1201.0862.3E-023.7E-0111.5102.2739.8E-065.1E-026.0E-061.8E-021.679
TUBB6ENSG0000017601431.1361.4264.5E-061.5E-020.6961.8858.8E-021.0E+ 009.0E-062.2E-021.656
VIMENSG00000026025297.9030.7017.8E-032.5E-011841.9551.2407.0E-051.5E-011.1E-052.2E-020.971
COL4A1ENSG0000018749894.9791.4241.6E-045.6E-0271.6591.0084.3E-037.6E-011.3E-052.2E-021.216
NFKBIAENSG00000100906280.1640.6729.7E-054.1E-028.0060.9328.9E-038.8E-011.5E-052.2E-020.802
MAT2AENSG00000168906766.7180.6416.1E-032.4E-011065.1430.9021.6E-042.0E-011.6E-052.2E-020.771
AEBP1ENSG00000106624238.3001.6382.1E-061.4E-0214.6820.3284.5E-011.0E+ 001.9E-052.2E-020.983
MSA-PGPNMBENSG0000013623587.5071.7981.5E-033.0E-0134.1161.7732.2E-057.7E-021.7E-062.0E-021.785
MSA-CPGAM2ENSG0000016470864.6181.9064.7E-043.6E-02230.0223.1933.5E-084.8E-052.7E-085.6E-052.549
ST5ENSG00000166444140.1631.2166.0E-077.8E-0479.4011.1468.8E-056.7E-034.8E-085.6E-051.181
STON1ENSG0000024324459.5701.5601.1E-035.7E-02433.9082.1771.0E-082.7E-052.3E-085.6E-051.868
RFTN1ENSG0000013137853.0432.4237.5E-078.6E-0466.9001.3456.2E-056.0E-034.5E-085.6E-051.884
ACTN1ENSG00000072110101.7331.9392.9E-059.3E-03141.2141.9055.7E-061.5E-038.6E-087.0E-051.922
MMP14ENSG0000015722768.0181.7401.5E-042.0E-02270.4062.1281.2E-065.8E-049.0E-087.0E-051.934
ITGB4ENSG00000132470425.3611.4911.2E-041.8E-02109.8631.6506.0E-061.5E-031.8E-071.2E-041.570
MAPK4ENSG00000141639274.8321.5613.6E-096.0E-0553.5340.4023.6E-016.5E-012.9E-071.7E-040.981
OMGENSG00000126861431.926−1.3842.3E-038.0E-0256.937−2.1852.5E-069.7E-046.0E-072.3E-04−1.785
FAM107AENSG000001683092370.5870.8489.9E-031.6E-012751.9101.7543.5E-072.7E-044.6E-072.3E-041.301
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