Fig. 6
From: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Comparison of molecular microglial signature in different brain regions of HDLS patients. The relative expression level of microglial-specific transcripts, IBA-1, P2RY12 and CX3CR1. All three genes have a trend of decreasing their level in HDLS cases. However, it is statistically significant only in frontal cortex white matter (P2RY12, p = 0.0033, CX3CR1, p = 0.0086). The relative expression level of CSF-1 and CSF-1R. The level of CSF-1 significantly increased both in white and gray matter. However, the level of CSF-1R significantly decreased only in white matter while it showed trend of increasing in gray matter. The box and whisker plot displays median values with the error bars of maximum and minimum values. Two tailed student t-test were used *p < 0.05, **p < 0.01, ***p < 0.005