Fig. 5
From: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Enrichment analyses with differentially expressed genes in frontal cortex white matter. a The number of up- and down-regulated genes in each brain region. FW, FG and CW are frontal cortex white matter (green), frontal cortex gray matter (pink) and cerebellum white matter (blue), respectively. b The overlap between HDLS specific transcriptional changes in different brain areas. A Venn diagram displays the number of differentially expressed genes in HDLS. The same color code was used to indicate each brain region. The total numbers of altered genes are shown in parenthesis. Overlapping portions of circles indicates the number of genes shown in multiple brain regions. Seventy-five genes are FW-specific and 24 genes are FG-specific. c Enriched pathway maps in frontal cortex white matter. Enrichment analysis was performed using 75 FW-specific genes. The table with top 25 pathways displays multiple CSF-1-involved pathways and a lot of immune response-related pathways. d Gene ontology process in frontal cortex white matter. Enrichment analysis was performed using 75 FW-specific. The table with top 25 processes includes cell migration, cell differentiation and axonal regeneration-related processes