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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

Fig. 4

Identification of brain region-specific transcriptional changes in HDLS. (a & b) Heat map and PCA map of total transcription profiles in different brain regions. The same color codes were used to display the same groups in (a) and (b). (a) The heat map shows that HDLS-cases are clearly separated from control-cases by their molecular signatures in frontal cortex white matter. Up- and down-regulated transcripts in HDLS are shown in red and blue, respectively. (b) The PCA components from FW are proximal to the CW than FG indicating the similarity in cellular structure-specific gene expression patterns. PCA 67.1%, PC1 = 33.3%, PC2 = 24%. (c-e) PCA analysis of total transcripts in each brain areas, FW, FG and CW. Control cases (n = 5) are shown in blue, and HDLS cases (n = 6) are shown in red marbles. FW, FG and CW samples were acquired from the same individual assigned with the number from 1 to 12 by individual, and assigned with the alphabet a-c by brain area. (c) PCA map of frontal cortex white matter, PCA 65.7%, PC1 81.5%, PC2 22.4% (d) PCA of frontal cortex gray matter, PCA 79.9%, PC1 46.6%, PC2 26.3% (e) PCA of cerebellum white matter, PCA 58.9%, PC1 26.7%, PC2 17.6%. FW, frontal cortex white matter; FG, frontal cortex gray matter; CW, cerebellum white matter; Ctl, control

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