Fig. 7

ALS-CSF altered the translational profiles of neurons. (a) Principal component analysis of the protein datasets for all the replicates across the groups. (b) Heatmap showing the pattern of regulation of the neuronal translatome across the groups. (c-d) Graph depicting fold changes (ALS vs NALS) in the prominently upregulated (red, c) and downregulated (blue, d) proteins. (e), Graph depicting the cellular (neuronal) components affected in response to ALS-CSF, when compared to NALS-CSF. (f, g). Pie charts describing the processes regulated by the proteins upregulated (f) and downregulated (g) in response to ALS-CSF (vs NALS-CSF). **p ≤ 0.01. (h) Overall network depicting the upregulated (red) as well as downregulated (blue) processes (ALS vs NALS). The analysis involved three biological replicates from NALS (n = 6) and ALS (n = 6) groups