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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Transmission of ALS pathogenesis by the cerebrospinal fluid

Fig. 5

ALS-CSF triggered cognitive and pathological changes in the brain. (a, b) Novel object recognition. Graphs depicting object preference by mice between the familiar and novel object (a) and the overall time spent in exploring the objects (b) (n = 6). (c) Graph depicting stereotypic count from the OFT analysis. (n = 6). (d) Cresyl violet staining of cortical sections across the groups. (e.h) Cortical sections stained (e.) for DAPI (blue) and TDP43 (green), and quantification for the N/C intensity of TDP43 (h). Expression patterns and quantification of the immunoblots for ChAT (f), phospho p65 (g), InA (i) GFAP (j), and NfL (k.) proteins in the cortical and hippocampal lysates. (n = 3). Data are mean ± SEM. (*p ≤ 0.05, **p ≤ 0.01, and *** p ≤ 0.001) and fold changes are calculated compared to NALS. Scale bar = 50 μm

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