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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Transmission of ALS pathogenesis by the cerebrospinal fluid

Fig. 2

Motor dysfunction and muscular pathology in response to ALS-CSF. (a) Changes in the paw extension reflex scores from day 1 to day 15 after CSF administration (n = 6). (b) Changes in body weight following CSF administration (n = 12). (c-g) Open field test (OFT) analysis. Representative images for the locomotor pattern (c) and quantitative data for total distance traveled (d), horizontal (e) and vertical (f) activity as well as the time spent at the center (g) by the mice during OFT (n = 6). (h-k) Gait analysis. Representative images for the gait pattern (h) and quantitative data summarizing the stance length (i) paw overlap (j) and stride length (k) (n = 6). (l-o) Muscle pathology. Panel (l) and graph (m) describe the morphological changes in the H&E stained muscle tissues. Panel (n) and graph (o) highlight the complete (yellow asterisk) or partial denervation of NMJ (yellow arrowhead) (n = 3 for each different experiment). Data are mean ± SEM. (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 and **** p ≤ 0.001) and fold changes are calculated compared to NALS. Scale bar = 20 μm

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