Fig. 3
From: Restoration of miR-193a expression is tumor-suppressive in MYC amplified Group 3 medulloblastoma
Effect of miR-193a expression on the anchorage-independent growth and the tumorigenicity of medulloblastoma cells. a Y-axis denotes the number of soft agar colonies formed by the indicated medulloblastoma cells, upon doxycycline treatment as a percentage of the untreated control cells. b, c In vivo bioluminescence images of the orthotopic tumors at day 2 and day 21 post-injection of doxycycline-treated vector control cells (Vector control) or miR-193a expressing medulloblastoma cells (MiR-193a) in the cerebellar region of the NOD/SCID mice. d Y-axis denotes the fold change in the tumor growth on day 21 compared to that on day two, as evaluated by the change in the average luminescence of the tumor area. e Kaplan Meier survival analysis of the mice injected with the doxycycline-treated vector control or miR-193a expressing medulloblastoma cells of the indicated cell line. P1, P2: Medulloblastoma cells expressing miR-193a upon doxycycline treatment. **, *** indicate p < 0.001, p < 0.0001 respectively. H.R. = Hazard Ratio