Fig. 4

HOXC8 protein is increased in plexiform orbitofacial neurofibromas compared with plexiform neurofibromas at other sites. a Immunohistochemical H-score for HOXC8 was increased in plexiform orbitofacial compared to plexiform non-orbitofacial. No statistical significant differences were seen in non-orbitofacial vs orbitofacial as a whole or cutaneous non-orbitofacial vs cutaneous orbitofacial (unpaired T-test with Welch’s correction). b No differences were noted between plexiform non-orbitofacial vs. plexiform orbitofacial immunoreactivity for HOXA6, HOXC4, and HOXD4 (unpaired T-test with Welch’s correction). c Representative images for H-score method assigned a score of 0–300 to each patient. The patient samples were classed as low (H-score 0–100), medium (100–200), and high (200–300). Forty-six orbitofacial and 31 non-orbitofacial neurofibromas were analyzed