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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

Fig. 3

Expression of AQP4 in 5xFAD mice. a qPCR analysis of brain hemispheres from wild-type (black columns), 5xFAD (red columns), and 5xFAD/AQP4 KO (blue columns) mice. Values are mean ± S.E.M of 5–6 individuals. *(P < 0.01) and **(P < 0.001) represent significant differences versus wild-type mice. b and c Comparison of AQP4 expression in the cortices of wild-type (b) and 5xFAD (c) mice. Perivascular staining of AQP4 is denoted by arrow heads. The expression of AQP4 around unstained spots is denoted by arrows. d and e Aberrant expression of AQP4 (d) was observed around amyloid plaques stained with Congo red (e). Scale bars = 250 μm (b and c) and 50 μm (d and e)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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