Fig. 2

Electroencephalography of 5xFAD female mice. a-f Representative electroencephalographic (EEG) traces from 4-month-old 5xFAD (a), 4-month-old 5xFAD/AQP4 KO (b), 10-month-old 5xFAD (c), 10-month-old 5xFAD/AQP4 KO (d), 12-month-old wild-type (e), and 12-month-old AQP4 KO (f) mice. Red circles indicate epileptiform activity. g Mean traces of epileptiform spike waveforms from 5xFAD (4 months), 5xFAD/AQP4 KO (4 months), 5xFAD (10 months), and 5xFAD/AQP4 KO (10 months) mice. h Mean epileptiform spike counts per minute were obtained from 5xFAD (4 months, n = 5), 5xFAD/AQP4 KO (4 months, n = 5), 5xFAD (10 months, n = 6), and 5xFAD/AQP4 KO (10 months, n = 10) mice. Values are mean ± S.E.M. * (P < 0.01) represents significant differences of 10-month-old 5xFAD/AQP4 KO versus each of the other groups