Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

Table 1 Summary of the neuropathological groups used in this study. Mean age, Braak NFT stage, AβMTL phase, CERAD score and NIA-AA degrees of AD pathology are indicated. Number of cases with each LATE-NC stage and respective percentages are also indicated (see also Additional file 1-Table A1). n.a. not applicable

Neuropathological Diagnosis	Mean age	Mean Braak NFT-stage	Mean CERAD score	Mean NIA-AA degree	Mean AβMTL phase	No LATE-NC	LATE-NC stage 1	LATE-NC stage 2	LATE-NC stage 3	n
Non-AD	61	0,8	0	0	0	17 (85%)	1 (5%)	2 (10%)	0 (0%)	20
p-preAD	76	1,9	0,19	1	2	5 (31,2%)	3 (18,8%)	8 (50%)	0 (0%)	16
AD^TDP-	78	3,7	1,4	2	3,5	10 (100%)	0 (0%)	0 (0%)	0 (0%)	10
AD^{TDP + CTF}	76	5,1	2,4	2,7	3,9	1 (3,3%)	1 (3,3%)	19 (63,4%)	9 (30%)	30
AD^TDP + FL	77	4,8	2,3	2,6	3,7	0 (0%)	0 (0%)	5 (45,5%)	6 (54,5%)	11
FTLD-TDP	65	1,2	0	0,4	0,6	n.a.	n.a.	n.a.	n.a.	10

ISSN: 2051-5960