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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

Fig. 7

ADTDP + FL cases have high amounts of p-τ, Aβ, and a high dementia score, comparable to ADTDP + CTF cases. a Braak NFT-stage, b AβMTL phase, c NIA-AA degree of AD pathology, d CERAD score, e CDR score and (f) age at death among neuropathological groups. No significant differences were found between these AD groups except for age. p-preAD, ADTDP-, ADTDP + CTF and ADTDP + FL cases were significantly older when compared to non-AD controls (p = 0.002, p < 0.0001, p < 0.0001 and p = 0.003, respectively). Non-parametric, Kruskal-Wallis test for independent samples with Bonferroni correction for multiple testing was used to compare the same independent variable among neuropathological groups. When limiting the sample to the AD groups and comparing ADTDP-, ADTDP + CTF, and ADTDP + FL cases, two by two with binary logistic regression analysis controlled for age and sex and adjusted for multiple testing by the Bonferroni procedure, ADTDP + CTF cases showed higher Braak NFT stages, AβMTL phases, CERAD scores, and NIA-AA degrees of AD pathology compared to ADTDP- cases (Additional file 1-Tables A8-A11)

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