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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

Fig. 4

pTDP-43 species are predominant in ADTDP + CTF whereas full-length TDP-43 is abundant in ADTDP + FL and FTLD-TDP. Immunohistochemistry of a non-AD, p-preAD, ADTDP + CTF, ADTDP + FL and FTLD-TDP case in the medial temporal lobe (a1-b5) with (a) PHF-τ, (b) Aβ (4G8). Scale bar = 1 mm. CA1-hippocampus (c1-g5) of a non-AD, p-preAD, ADTDP + CTF, ADTDP + FL and FTLD-TDP with (c) pTDP-43409/410 (clone 1D3), (d) pTDP-43409, (e) pTDP-43403/404 (f) C-t TDP-43 and (g) N-t TDP-43 antibodies. NCIs and NFT-like lesions are detected in p-preAD and ADTDP + CTF cases with pTDP-43409/410 (c3, arrows) and pTDP-43409 (d2-d3, arrows), but not pTDP-43403/404 (e2-e3). Nuclei are stained with C- and N-t-TDP-43 antibodies and unstained, “ghost” NFTs, NCIs and GVD are apparent (f2,g2-g3 arrowheads, f3 inset, arrowheads) in p-preAD and ADTDP + CTF cases. NCIs and DNs are detected in ADTDP + FL and FTLD-TDP with pTDP-43409/410 (c4-c5 respectively, arrows), pTDP-43409 (d4-d5 respectively, DNs, arrows), pTDP403/404 (e4-e5 respectively, DNs, arrows), C-t (f4-f5 respectively, NCI and DN are indicated with arrows, respectively) and N-t-TDP-43 (g4-g5, NCI and two DNs are indicated with arrows, respectively). ADTDP- cases were not included in this figure because no TDP-43 inclusions were observed. Scale bar = 50 μm

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