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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

Fig. 3

Amount of positive cases for lesions detected with pTDP-43409/410, pTDP-43409, pTDP-43403/404, C- and N-t-TDP-43 in (a, d) dentate gyrus, (b, e) CA1 and (c, f) temporal cortex, according to a neuropathological classification (non-AD, p-preAD, ADTDP-, ADTDP + CTF, ADTDP + FL and FTLD-TDP) (a-c), or further grouped by clinical diagnosis (non-demented – including neuropathological non-AD and p-preAD cases, sympAD – all cases with an exclusive AD clinical presentation, AD/FTD – cases with signs of AD as well as FTD symptoms, and FTD – cases with an exclusive FTD clinical presentation) (d-f). Non-parametric, Friedman test for related samples with Bonferroni correction for multiple testing was used to compare the amount of positive cases with each TDP-43 antibody within each clinical group. Each group was analyzed separately, *p < 0.05, **p < 0.01

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