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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 5

Unilateral intranigral administration of BSSG causes bilateral loss of neuronal cytoskeleton immunoreactivity. a Representative merged micrographs of double immunostaining against β-III tubulin (green) and TH (red) at the time displayed at the left margin in every row. b The graphs represent the IFAD for β-III tubulin and TH in the conditions of the panel a. The bars stand for the mean ± S.E.M. calculated from the measurements in three anatomical levels. n = 3 independent rats per time point in the BSSG group; n = 6 for Mock and UT groups. $, UT group compared with the mock group. *, Φ, BSSG group compared with the control groups. When compared with the BSSG effect over time, Ω vs. 120 days after the lesion. Two-way ANOVA, Bonferroni post-test. p < 0.05. Representative micrographs of cytoskeleton details in the SNpc of c mock condition and d injured condition at days 30 and e 120 after the BSSG injection. The scale bar = 50 μm is common for all micrographs in panel a and = 20 μm for the magnified images

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