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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 4

Unilateral intranigral administration of BSSG decreases TH (+) innervation in the striatum. Representative micrographs of TH immunohistochemical staining of a the injured and b control side (time points displayed at the bottom). The scale bars = 1 mm are common for all micrographs. The graphs show TH (+) optical density of the b injured and d control side. The values are the mean ± S.E.M. calculated from the measurements in three anatomical levels. n = 3 independent rats per each time in the BSSG group. The dashed lines correspond to the mock group (black squares; n = 6 independent rats) and the UT group (white circles; n = 6 independent rats). *, significant when compared with the control groups. When compared with the BSSG effect over time, the significance is marked with & vs. 60 and Ω vs. 120 days after the lesion. Two-way ANOVA, Bonferroni post-test. p < 0.05

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Acta Neuropathologica Communications

ISSN: 2051-5960

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