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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 3

Unilateral intranigral administration of BSSG decreases TH (+) cells and their branches in midbrain nuclei. a Representative micrographs of TH immunohistochemical staining of mesencephalon slices. Times are displayed at the left margin in every row. The scale bars equal 1 mm for the panoramic views and 100 μm for the 20X zooms. b Graphs showing TH (+) cell counting in the injured SNpc, VTA, and control SNpc. c The area density of TH (+) arborization was measured in the injured and control SNPr. The values are the mean ± S.E.M. from three anatomical levels. n = 3 independent rats per time point in the BSSG group. The dashed lines correspond to the mock group (black squares; n = 6 independent rats) and the UT group (white circles; n = 6 independent rats). *, significant when compared with the control groups. When compared with the BSSG effect over time, the significance is marked with & vs. 60 and Ω vs. 120 days after the lesion. Two-way ANOVA, Bonferroni post-test. p < 0.05

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