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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 2

A single unilateral intranigral BSSG administration triggers progressive and bilateral pathological α-synuclein aggregates in the M1-cortex and DL-striatum. a Representative micrographs of pathological α-synuclein immunostaining in the injured side at the time displayed at the left in every row, evidencing cytoplasmic (black arrowhead) and dendritic (blue arrowhead) aggregation. The scale bar = 15 μm is common for all micrographs. b Schematic representation of coronal slices at three different levels showing the distribution of pathological α-synuclein over time. c Graphs showing the α-synuclein (+) area density on the injured and control sides of the M1-cortex and DL-striatum according to classification in Paxinos and Watson Atlas, 1998. The values are the mean ± S.E.M. calculated from the measurements in three anatomical levels. n = 3 independent rats per each time in the BSSG group. The dashed lines correspond to the mock group (black square; n = 6 independent rats) and UT group (white circle; n = 6 independent rats). Φ,*, significant when BSSG group compared with the control groups. Two-way ANOVA, Bonferroni post-test. p < 0.05

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