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Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 10

A single intranigral BSSG administration triggers bilateral morphologic changes and the density of dendritic spines in medium spiny neurons. a Representative micrographs showing Golgi–Cox-impregnated dendrites and spines of the mock and BSSG groups. The scale bar is 100 μm for panoramic views and 10 μm for amplifications. The graphs show the spine density (b) and the percentage of different spine types: stubby (c) mushroom (d), thin (e), multi-headed (f), and branched (g). The bars stand for the mean ± S.E.M. n = 4–6 independent rats per each group. *, BSSG group compared with the mock group. Two-way ANOVA, Bonferroni post-test. p < 0.05

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