Skip to main content

Table 1 Loss of significance in enriched pathways

From: Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition

Up-regulated Down-regulated
Pathway Delta Pathway Delta
myelination −8.85 regulation of synaptic vesicle exocytosis −9.63
ensheathment of neurons −8.67 intrinsic component of synaptic membrane −9.60
axon ensheathment −8.67 regulation of synaptic vesicle cycle −9.58
detection of chemical stimulus involved in sensory perception of bitter taste −7.95 positive regulation of synaptic transmission −9.48
oligodendrocyte differentiation − 6.94 Schaffer collateral - CA1 synapse −9.46
oligodendrocyte development −6.58 regulation of synaptic plasticity −9.44
apical junction complex −5.57 regulation of neurotransmitter secretion −9.41
glial cell development −5.54 presynaptic membrane −9.27
glial cell differentiation −5.52 regulation of synaptic vesicle transport −9.19
tight junction −4.16 protein transport within lipid bilayer −9.11
Up-regulated Down-regulated
Pathway Delta Pathway Delta
activation of innate immune response −8.54 ribonucleoside monophosphate metabolic process −9.09
regulation of leukocyte proliferation −8.11 purine nucleoside triphosphate metabolic process −9.03
regulation of lymphocyte proliferation −8.01 mitochondrial membrane part −8.99
regulation of mononuclear cell proliferation −7.79 ATP metabolic process −8.92
innate immune response-activating signal transduction −7.43 regulation of synaptic vesicle exocytosis −8.87
regulation of adaptive immune response −7.16 inner mitochondrial membrane protein complex −8.82
response to interferon-gamma −7.15 purine ribonucleoside triphosphate metabolic process −8.77
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains −7.07 respiratory chain −8.70
blood microparticle −6.75 regulation of synaptic vesicle transport −8.68
regulation of T cell proliferation −6.73 cellular respiration −8.43
  1. Tables representing the top 10 pathways with the lowest delta for up- and down-regulated pathways for PW and NBB cohorts. The delta value represents the change in the enrichment –log10 (p-value) between the results with and without MGP adjustment (negative values of delta imply a loss of significance when accounting for cellularity). Complete results are provided in Additional file 6