Table 1 Loss of significance in enriched pathways
From: Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition
PW | |||
Up-regulated | Down-regulated | ||
Pathway | Delta | Pathway | Delta |
myelination | −8.85 | regulation of synaptic vesicle exocytosis | −9.63 |
ensheathment of neurons | −8.67 | intrinsic component of synaptic membrane | −9.60 |
axon ensheathment | −8.67 | regulation of synaptic vesicle cycle | −9.58 |
detection of chemical stimulus involved in sensory perception of bitter taste | −7.95 | positive regulation of synaptic transmission | −9.48 |
oligodendrocyte differentiation | − 6.94 | Schaffer collateral - CA1 synapse | −9.46 |
oligodendrocyte development | −6.58 | regulation of synaptic plasticity | −9.44 |
apical junction complex | −5.57 | regulation of neurotransmitter secretion | −9.41 |
glial cell development | −5.54 | presynaptic membrane | −9.27 |
glial cell differentiation | −5.52 | regulation of synaptic vesicle transport | −9.19 |
tight junction | −4.16 | protein transport within lipid bilayer | −9.11 |
NBB | |||
Up-regulated | Down-regulated | ||
Pathway | Delta | Pathway | Delta |
activation of innate immune response | −8.54 | ribonucleoside monophosphate metabolic process | −9.09 |
regulation of leukocyte proliferation | −8.11 | purine nucleoside triphosphate metabolic process | −9.03 |
regulation of lymphocyte proliferation | −8.01 | mitochondrial membrane part | −8.99 |
regulation of mononuclear cell proliferation | −7.79 | ATP metabolic process | −8.92 |
innate immune response-activating signal transduction | −7.43 | regulation of synaptic vesicle exocytosis | −8.87 |
regulation of adaptive immune response | −7.16 | inner mitochondrial membrane protein complex | −8.82 |
response to interferon-gamma | −7.15 | purine ribonucleoside triphosphate metabolic process | −8.77 |
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | −7.07 | respiratory chain | −8.70 |
blood microparticle | −6.75 | regulation of synaptic vesicle transport | −8.68 |
regulation of T cell proliferation | −6.73 | cellular respiration | −8.43 |