Fig. 3
From: Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity
5xFAD serum contains Aβ-associated astrosomes that are taken up by neural cells Representative images of N2a cells incubated with exosomes isolated from wild type (WT) (a, d) or 5xFAD serum (b, e)and coimmunolabeled with antibodies against GFAP and ceramide (a, b) or flotillin-2 and Aβ (d, e). Arrows point at cells with uptake of Aβ-associated exosomes. The Pearson’s correlation coefficient was calculated to compare colocalization of GFAP and ceramide (c) or flotillin-2 and Aβ signals (f) in WT (open bar) and 5xFAD (closed bar). Welch’s t-test, *p < 0.05. N = 6