Fig. 2
From: Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity
5xFAD serum astrosomes associated with Aβ form aggregates, which is reduced by the novel ceramide analog S18.a Gel electrophoresis after immune capturing of exosomes on beads using either ceramide antibody or control IgG and probing with anti-GFAP antibody. Blot is representative of the results from three independent experiments. b Dot blot against Aβ using flow through for the same experiment. c Size distribution of wild type (WT), 5xFAD, and 5xFAD exosomes treated with anti-ceramide IgG. d Size distribution of WT, 5xFAD, and 5xFAD exosomes treated with the novel ceramide analog S18. Particle diameter of each sample is represented as ±SEM, two-way ANOVA, *p < 0.05. N = 4